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PEPDar: A randomized prospective noninferiority study of ritonavir-boosted darunavir for HIV post-exposure prophylaxis

Fätkenheuer, G. ; Jessen, H. ; Stoehr, A. ; Jung, N. ; Jessen, A. B. ; Kümmerle, T. ; Berger, M. ; Bogner, J. R. ; Spinner, C. D. ; Stephan, C. ; Degen, O. ; Vogelmann, R. ; Spornraft-Ragaller, P. ; Schnaitmann, E. ; Jensen, B. ; Ulmer, A. ; Kittner, J. M. ; Härter, G. ; Malfertheiner, P. ; Rockstroh, J. ; Knecht, G. ; Scholten, S. ; Harrer, T. ; Kern, W. V. ; Salzberger, B. ; Schürmann, D. ; Ranneberg, B.



Abstract

ObjectivesPEPDar compared the tolerability and safety of ritonavir-boosted darunavir (DRV/r)-based post-exposure prophylaxis (PEP) with the tolerability and safety of standard of care (SOC). The primary endpoint was the early discontinuation rate among the per-protocol population. MethodsPEPDar was an open-label, randomized, multicentre, prospective, noninferiority safety study. Subjects were ...

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