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PEPDar: A randomized prospective noninferiority study of ritonavir-boosted darunavir for HIV post-exposure prophylaxis

Fätkenheuer, G ; Jessen, H ; Stoehr, A ; Jung, N ; Jessen, AB ; Kümmerle, T ; Berger, M ; Bogner, JR ; Spinner, CD ; Stephan, C ; Degen, O ; Vogelmann, R ; Spornraft-Ragaller, P ; Schnaitmann, E ; Jensen, B ; Ulmer, A ; Kittner, JM ; Härter, G ; Malfertheiner, P ; Rockstroh, J ; Knecht, G ; Scholten, S ; Harrer, T ; Kern, WV ; Salzberger, B ; Schürmann, D ; Ranneberg, B



Abstract

ObjectivesPEPDar compared the tolerability and safety of ritonavir-boosted darunavir (DRV/r)-based post-exposure prophylaxis (PEP) with the tolerability and safety of standard of care (SOC). The primary endpoint was the early discontinuation rate among the per-protocol population. MethodsPEPDar was an open-label, randomized, multicentre, prospective, noninferiority safety study. Subjects were ...

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