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The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway

Monin, Malte B. ; Krause, Petra ; Stelling, Robin ; Bocuk, Derya ; Niebert, Sabine ; Klemm, Florian ; Pukrop, Tobias ; Koenig, Sarah



Abstract

Background: Wnt/beta-catenin signaling is known to play an important role in colorectal cancer (CRC). Niclosamide, a salicylamide derivative used in the treatment of tapeworm infections, targets the Wnt/beta-catenin pathway. The objective of this study was to investigate niclosamide as a therapeutic agent against CRC. Methods: The antiproliferative effects of 1, 3, 10, and 50 mu M concentrations ...

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