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Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

Bain, Calum C. ; Hawley, Catherine A. ; Garner, Hannah ; Scott, Charlotte L. ; Schridde, Anika ; Steers, Nicholas J. ; Mack, Matthias ; Joshi, Anagha ; Guilliams, Martin ; Mowat, Allan Mc I. ; Geissmann, Frederic ; Jenkins, Stephen J.



Abstract

Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the composition, developmental origin and mechanisms governing the maintenance of this compartment are controversial. Here we show resident F4/80(hi)GATA6(+) macrophages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin for at least 4 months in mice. However, Ly6C(+) ...

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