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The induction of cellular senescence in dental follicle cells inhibits the osteogenic differentiation

Morsczeck, Christian ; Gresser, Jan ; Ettl, Tobias


Dental stem cells such as human dental follicle cells (DFCs) have opened new promising treatment alternatives for today's dental health issues such as periodontal tissue regeneration. However, cellular senescence represents a restricting factor to cultured stem cells, resulting in limited lifespan and reduced cell differentiation potential. Therefore, this study evaluated if and how DFCs exhibit ...


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