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Cellular Pathophysiology of an Adrenal Adenoma-Associated Mutant of the Plasma Membrane Ca2+-ATPase ATP2B3

Tauber, Philipp ; Aichinger, B. ; Christ, C. ; Stindl, J. ; Rhayem, Y. ; Beuschlein, F. ; Warth, R. ; Bandulik, S.



Abstract

Adrenal aldosterone-producing adenomas (APAs) are a main cause for primary aldosteronism leading to arterial hypertension. Physiologically, aldosterone production in the adrenal gland is stimulated by angiotensin II and high extracellular potassium. These stimuli lead to a depolarization of the plasma membrane and, as a consequence, an increase of intracellular Ca2+. Mutations of the plasma ...

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