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Short-term heat pre-treatment modulates the release of HMGB1 and pro-inflammatory cytokines in hPDL cells following mechanical loading and affects monocyte behavior

Wolf, Michael ; Lossdörfer, Stefan ; Römer, Piero ; Kirschneck, Christian ; Küpper, Katharina ; Deschner, James ; Jäger, Andreas



Abstract

Heat shock proteins (HSP) act as cell-protective molecules that are upregulated upon thermal insult, hypoxia, and ischemia. Such ischemic conditions can be found during tissue remodeling associated with orthodontic tooth movement or trauma when compression forces lead to cell necrosis and subsequent clearance of cellular debris by immune competent cells. Host immune overreaction can result in ...

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