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CD4+T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients

Dubinski, Daniel ; Wölfer, Johannes ; Hasselblatt, Martin ; Schneider-Hohendorf, Tilman ; Bogdahn, Ulrich ; Stummer, Walter ; Wiendl, Heinz ; Grauer, Oliver M.



Abstract

Background. Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of myeloid cells that are significantly expanded in cancer patients and are associated with tumor progression. Methods. Multicolor flow cytometry was used to study the frequency, phenotype, and function of MDSCs in peripheral blood and freshly resected tumors of 52 participants with primary glioblastoma ...

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