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RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells

Hesbacher, Sonja ; Pfitzer, Lisa ; Wiedorfer, Katharina ; Angermeyer, Sabrina ; Borst, Andreas ; Haferkamp, Sebastian ; Scholz, Claus-Jürgen ; Wobser, Marion ; Schrama, David ; Houben, Roland


The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing tumor suppressive properties. Indeed, the PPs jointly control the G1/S transition mainly by inhibiting E2F transcription factors. Notably, several viral oncoproteins are capable of binding and inhibiting PPs. Merkel cell polyomavirus (MCPyV) is considered as etiological factor for Merkel cell carcinoma ...


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