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Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice

Maass, Thorsten ; Marquardt, Jens ; Lee, Ju-Seog ; Krupp, Markus ; Scholz-Kreisel, Peter ; Mogler, Carolin ; Schirmacher, Peter ; Müller, Martina ; Westphal, Heiner ; Galle, Peter R. ; Teufel, Andreas



Zusammenfassung

Dkk2 a antagonist of the Wnt/beta-catenin-signaling pathway was shown to be silenced in diverse cancers. More recent data indicate that Dkk family members may also possess functions independent of Wnt-signaling during carcinogenesis. The detailed biological function of Dkks and its relevance for liver cancer is unknown. We analyzed the effects of a genetic deletion of Dkk2 (Dkk2(-/-)) in a ...

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