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Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis

Matz-Soja, Madlen ; Rennert, Christiane ; Schönefeld, Kristin ; Aleithe, Susanne ; Boettger, Jan ; Schmidt-Heck, Wolfgang ; Weiss, Thomas S ; Hovhannisyan, Amalya ; Zellmer, Sebastian ; Klöting, Nora ; Schulz, Angela ; Kratzsch, Jürgen ; Guthke, Reinhardt ; Gebhardt, Rolf


Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and is increasing in prevalence. The pathomechanisms, however, are poorly understood. This study assessed the unexpected role of the Hedgehog pathway in adult liver lipid metabolism. Using transgenic mice with conditional hepatocyte-specific deletion of Smoothened in adult mice, we showed that ...


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