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A Depleting Anti-CD45 Monoclonal Antibody as Isolated Conditioning for Bone Marrow Transplantation in the Rat

Doering, Christopher B ; Jäger, Mark D. ; Vondran, Florian W. R. ; Ramackers, Wolf ; Röseler, Tilmann ; Schlitt, Hans J. ; Bektas, Hüseyin ; Klempnauer, Jürgen ; Timrott, Kai



Abstract

Objective A monoclonal antibody (mAb) against the leukocyte common antigen CD45 (RT7 in rats) could facilitate bone marrow transplantation (BMT). This study in rats evaluates a depletive rat anti-RT7(a) mAb as isolated tool for BMT conditioning without using irradiation or any chemotherapeutic /immunosuppressive agent. Methods The model used a CD45 di-allelic polymorphism (RT7(a)/RT7(b)). The ...

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