Go to content
UR Home

The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology

Hartmann, Nico ; Mason, Fleur E. ; Braun, Inga ; Pabel, Steffen ; Voigt, Niels ; Schotola, Hanna ; Fischer, Thomas H. ; Dobrev, Dobromir ; Danner, Bernhard C. ; Renner, André ; Gummert, Jan ; Belardinelli, Luiz ; Frey, Norbert ; Maier, Lars S. ; Hasenfuss, Gerd ; Sossalla, Samuel


Introduction: Pharmacological rhythm control of atrial fibrillation (AF) in patients with structural heart disease is limited. Ranolazine in combination with low dose dronedarone remarkably reduced AF-burden in the phase II HARMONY trial. We thus aimed to investigate the possible mechanisms underlying these results. Methods and results: Patch clamp experiments revealed that ranolazine (5 mu M), ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons