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The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology

Hartmann, Nico ; Mason, Fleur E. ; Braun, Inga ; Pabel, Steffen ; Voigt, Niels ; Schotola, Hanna ; Fischer, Thomas H. ; Dobrev, Dobromir ; Danner, Bernhard C. ; Renner, André ; Gummert, Jan ; Belardinelli, Luiz ; Frey, Norbert ; Maier, Lars S. ; Hasenfuss, Gerd ; Sossalla, Samuel



Abstract

Introduction: Pharmacological rhythm control of atrial fibrillation (AF) in patients with structural heart disease is limited. Ranolazine in combination with low dose dronedarone remarkably reduced AF-burden in the phase II HARMONY trial. We thus aimed to investigate the possible mechanisms underlying these results. Methods and results: Patch clamp experiments revealed that ranolazine (5 mu M), ...

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