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CD83 Modulates B Cell Activation and Germinal Center Responses

Krzyzak, Lena ; Seitz, Christine ; Urbat, Anne ; Hutzler, Stefan ; Ostalecki, Christian ; Gläsner, Joachim ; Hiergeist, Andreas ; Gessner, André ; Winkler, Thomas H. ; Steinkasserer, Alexander ; Nitschke, Lars



Abstract

CD83 is a maturation marker for dendritic cells. In the B cell lineage, CD83 is expressed especially on activated B cells and on light zone B cells during the germinal center (GC) reaction. The function of CD83 during GC responses is unclear. CD83(-/-) mice have a strong reduction of CD4(+) T cells, which makes it difficult to analyze a functional role of CD83 on B cells during GC responses. ...

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