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NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

Spalinger, Marianne R. ; Kasper, Stephanie ; Gottier, Claudia ; Lang, Silvia ; Atrott, Kirstin ; Vavricka, Stephan R. ; Scharl, Sylvie ; Gutte, Petrus M. ; Grütter, Markus G. ; Beer, Hans-Dietmar ; Contassot, Emmanuel ; Chan, Andrew C. ; Dai, Xuezhi ; Rawlings, David J. ; Mair, Florian ; Becher, Burkhard ; Falk, Werner ; Fried, Michael ; Rogler, Gerhard ; Scharl, Michael


Inflammasomes form as the result of the intracellular presence of danger-associated molecular patterns and mediate the release of active IL-1 beta, which influences a variety of inflammatory responses. Excessive inflammasome activation results in severe inflammatory conditions, but physiological IL-1 beta secretion is necessary for intestinal homeostasis. Here, we have described a mechanism of ...


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