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Non-essential contribution of LRRC8A to volume regulation

Sirianant, Lalida ; Wanitchakool, Podchanart ; Ousingsawat, Jiraporn ; Benedetto, Roberta ; Zormpa, Anna ; Cabrita, Ines ; Schreiber, Rainer ; Kunzelmann, Karl


Volume regulation is an essential property of any living cell and needs to be tightly controlled. While different types of K+ channels have been found to participate in the regulation of cell volume, the newly identified volume-regulated anion channel (VRAC) LRRC8 has been claimed to be essential for volume regulation. In unbiased genome-wide small interfering RNA (siRNA) screens, two independent ...


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