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iPLA2β deficiency attenuates obesity and hepatic steatosis in ob / ob mice through hepatic fatty-acyl phospholipid remodeling

Deng, Xiuling ; Wang, Jiliang ; Jiao, Li ; Utaipan, Tanyarath ; Tuma-Kellner, Sabine ; Schmitz, Gerd ; Liebisch, Gerhard ; Stremmel, Wolfgang ; Chamulitrat, Walee



Abstract

PLA2G6 or GVIA calcium-independent PLA2 (iPLA2 beta) is identified as one of the NAFLD modifier genes in humans, and thought to be a target for NAFLD therapy. iPLA2 beta is known to play a house-keeping role in phospholipid metabolism and remodeling. However, its role in NAFLD pathogenesis has not been supported by results obtained from high-fat feeding of iPLA2 beta-null (PKO) mice. Unlike ...

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