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The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21

Loss, Georg J. ; Depner, Martin ; Hose, Alexander J. ; Genuneit, Jon ; Karvonen, Anne M. ; Hyvärinen, Anne ; Roduit, Caroline ; Kabesch, Michael ; Lauener, Roger ; Pfefferle, Petra Ina ; Pekkanen, Juha ; Dalphin, Jean-Charles ; Riedler, Josef ; Braun-Fahrländer, Charlotte ; von Mutius, Erika ; Ege, Markus J.


Rationale: Growing up on a farm protects from childhood asthma and early wheeze. Virus-triggered wheeze in infancy predicts asthma in individuals with a genetic asthma risk associated with chromosome 17q21. Objectives: To test environmental determinants of infections and wheeze in the first year of life, potential modifications of these associations by 17q21, and the implications for different ...


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