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Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques

Wang, Shixia ; Zurawski, Gerard ; Zurawski, Sandra ; Flamar, Anne-Laure ; Richert, Laura ; Wagner, Ralf ; Tomaras, Georgia D. ; Montefiori, David C. ; Roederer, Mario ; Ferrari, Guido ; Lacabaratz, Christine ; Bonnabau, Henri ; Klucar, Peter ; Wang, Zhiqing ; Foulds, Kathryn E. ; Kao, Shing-Fen ; Yates, Nicole L. ; LaBranche, Celia ; Jacobs, Bertram L. ; Kibler, Karen ; Asbach, Benedikt ; Kliche, Alexander ; Salazar, Andres ; Reed, Steve ; Self, Steve ; Gottardo, Raphael ; Galmin, Lindsey ; Weiss, Deborah ; Cristillo, Anthony ; Thiebaut, Rodolphe ; Pantaleo, Giuseppe ; Levy, Yves



Abstract

Improved antigenicity against HIV-1 envelope (Env) protein is needed to elicit vaccine-induced protective immunity in humans. Here we describe the first tests in non-human primates (NHPs) of Env gp140 protein fused to a humanized anti-LOX-1 recombinant antibody for delivering Env directly to LOX-1-bearing antigen presenting cells, especially dendritic cells (DC). LOX-1, or 1ectin-like oxidized ...

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