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miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction

Gigante, Margherita ; Pontrelli, Paola ; Herr, Wolfgang ; Gigante, Maddalena ; D’Avenia, Morena ; Zaza, Gianluigi ; Cavalcanti, Elisabetta ; Accetturo, Matteo ; Lucarelli, Giuseppe ; Carrieri, Giuseppe ; Battaglia, Michele ; Storkus, Walter J. ; Gesualdo, Loreto ; Ranieri, Elena



Abstract

Background: Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. Since T cell dysfunction has previously been reported in patients with renal cell carcinoma (RCC; clear cell type), we aimed to analyze these immune cells for genetic and protein differences when compared to normal donor T cells freshly after ...

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