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Norrin mediates angiogenic properties via the induction of insulin-like growth factor-1

Zeilbeck, Ludwig F. ; Müller, Birgit B. ; Leopold, Stephanie A. ; Senturk, Berna ; Langmann, Thomas ; Tamm, Ernst R. ; Ohlmann, Andreas


Norrin is an angiogenic signaling molecule that activates canonical Wnt/beta-catenin signaling, and is involved in capillary formation in retina and brain. Moreover, Norrin induces vascular repair following an oxygen-induced retinopathy (OIR), the model of retinopathy of prematurity in mice. Since insulin-like growth factor (IGF)-1 is a very potent angiogenic molecule, we investigated if IGF-1 is ...


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