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Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens

Asbach, Benedikt ; Kliche, Alexander ; Köstler, Josef ; Perdiguero, Beatriz ; Esteban, Mariano ; Jacobs, Bertram L. ; Montefiori, David C. ; LaBranche, Celia C. ; Yates, Nicole L. ; Tomaras, Georgia D. ; Ferrari, Guido ; Foulds, Kathryn E. ; Roederer, Mario ; Landucci, Gary ; Forthal, Donald N. ; Seaman, Michael S. ; Hawkins, Natalie ; Self, Steven G. ; Sato, Alicia ; Gottardo, Raphael ; Phogat, Sanjay ; Tartaglia, James ; Barnett, Susan W. ; Burke, Brian ; Cristillo, Anthony D. ; Weiss, Deborah E. ; Francis, Jesse ; Galmin, Lindsey ; Ding, Song ; Heeney, Jonathan L. ; Pantaleo, Giuseppe ; Wagner, Ralf ; Silvestri, G.



Abstract

In a follow-up to the modest efficacy observed in the RV144 trial, researchers in the HIV vaccine field seek to substantiate and extend the results by evaluating other poxvirus vectors and combinations with DNA and protein vaccines. Earlier clinical trials (EuroVacc trials 01 to 03) evaluated the immunogenicity of HIV-1 clade C GagPolNef and gp120 antigens delivered via the pox-viral vector ...

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