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Effects of IP3R2 Receptor Deletion in the Ischemic Mouse Retina

Wagner, Lysann ; Pannicke, Thomas ; Frommherz, Ina ; Sauer, Katja ; Chen, Ju ; Grosche, Antje



Abstract

Glial cells in the diseased nervous system undergo a process known as reactive gliosis. Gliosis of retinal Muller glial cells is characterized by an upregulation of glial fibrillary acidic protein and frequently by a reduction of inward K+ current amplitudes. Purinergic signaling is assumed to be involved in gliotic processes. As previously shown, lack of the nucleotide receptor P2Y(1) leads to ...

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