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Transcription Profile in Sporadic Multiple Symmetric Lipomatosis Reveals Differential Expression at the Level of Adipose Tissue–Derived Stem Cells

Prantl, Lukas ; Schreml, Julia ; Gehmert, Sebastian ; Klein, Silvan ; Bai, Xiaowen ; Zeitler, Katharina ; Schreml, Stephan ; Alt, Eckhard ; Gehmert, Sanga ; Felthaus, Oliver



Abstract

Background: The cause of the rare fat distribution disorder multiple symmetric lipomatosis is unknown. Independent reports suggest a higher proliferative activity, hormone resistance, and involvement of mitochondrial function in the disease. Methods: The authors performed morphologic comparison of affected and unaffected tissues in five unrelated patients and generated adipose-derived stem cell ...

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