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Driving allotolerance: CAR-expressing Tregs for tolerance induction in organ and stem cell transplantation

Edinger, Matthias



Abstract

Regulatory T cells (Tregs) modulate the function of a variety of immune cells and are critical for maintaining self-tolerance and preventing the development of autoimmune disease. Due to their ability to suppress effector T cells, Tregs have been increasingly explored for clinical use to suppress alloresponses. While this approach has been promising in preclinical models and early clinical ...

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