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Cyclosporine A Inhibits the T-bet-Dependent Antitumor Response of CD8+T Cells

Rovira, J. ; Renner, P. ; Sabet-Baktach, M. ; Eggenhofer, E. ; Koehl, G. E. ; Lantow, M. ; Lang, S. A. ; Schlitt, H. J. ; Campistol, J. M. ; Geissler, E. K. ; Kroemer, A.



Abstract

Transplant recipients face an increased risk of cancer compared with the healthy population. Although several studies have examined the direct effects of immunosuppressive drugs on cancer cells, little is known about the interactions between pharmacological immunosuppression and cancer immunosurveillance. We investigated the different effects of rapamycin (Rapa) versus cyclosporine A (CsA) on ...

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