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Effects of catheter-based renal denervation on cardiac sympathetic activity and innervation in patients with resistant hypertension

Donazzan, Luca ; Mahfoud, Felix ; Ewen, Sebastian ; Ukena, Christian ; Cremers, Bodo ; Kirsch, Carl-Martin ; Hellwig, Dirk ; Eweiwi, Tareq ; Ezziddin, Samer ; Esler, Murray ; Böhm, Michael


To investigate, whether renal denervation (RDN) has a direct effect on cardiac sympathetic activity and innervation density. RDN demonstrated its efficacy not only in reducing blood pressure (BP) in certain patients, but also in decreasing cardiac hypertrophy and arrhythmias. These pleiotropic effects occur partly independent from the observed BP reduction. Eleven patients with resistant ...


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