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TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle

Schulz, Sarah ; Gietl, Andreas ; Smollett, Katherine ; Tinnefeld, Philip ; Werner, Finn ; Grohmann, Dina



Abstract

Transcription is an intrinsically dynamic process and requires the coordinated interplay of RNA polymerases (RNAPs) with nucleic acids and transcription factors. Classical structural biology techniques have revealed detailed snapshots of a subset of conformational states of the RNAP as they exist in crystals. A detailed view of the conformational space sampled by the RNAP and the molecular ...

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