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Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade

Schmidt, Melissa ; Mock, Andreas ; Jungk, Christine ; Sahm, Felix ; Ull, Anna Theresa ; Warta, Rolf ; Lamszus, Katrin ; Gousias, Konstantinos ; Ketter, Ralf ; Roesch, Saskia ; Rapp, Carmen ; Schefzyk, Sebastian ; Urbschat, Steffi ; Lahrmann, Bernd ; Kessler, Almuth F. ; Löhr, Mario ; Senft, Christian ; Grabe, Niels ; Reuss, David ; Beckhove, Philipp ; Westphal, Manfred ; von Deimling, Andreas ; Unterberg, Andreas ; Simon, Matthias ; Herold-Mende, Christel



Abstract

Meningiomas are frequent central nervous system tumors. Although most meningiomas are benign (WHO grade I) and curable by surgery, WHO grade II and III tumors remain therapeutically challenging due to frequent recurrence. Interestingly, relapse also occurs in some WHO grade I meningiomas. Hence, we investigated the transcriptional features defining aggressive (recurrent, malignantly progressing ...

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