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Immunogenicity of dimorphic and C-terminal fragments of Plasmodium falciparum MSP2 formulated with different adjuvants in mice

Balam, Saidou ; Jafarshad, Ali ; Servis, Catherine ; Frank, Geraldine ; Reed, Steve ; Pink, Richard ; Druilhe, Pierre ; Spertini, François ; Corradin, Giampietro



Abstract

Background: Plasmodium falciparum MSP2 is a blood stage protein that is associated with protection against malaria. It was shown that the MSP2 dimorphic (D) and constant (C) regions were well recognized by immune human antibodies, and were characterized by major conserved epitopes in different endemic areas and age groups. These Abs recognized merozoite-derived proteins in WB and IFA. Here, the ...

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