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A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion

Abu Kwaik, Yousef ; Andritschke, Daniel ; Dilling, Sabrina ; Emmenlauer, Mario ; Welz, Tobias ; Schmich, Fabian ; Misselwitz, Benjamin ; Rämö, Pauli ; Rottner, Klemens ; Kerkhoff, Eugen ; Wada, Teiji ; Penninger, Josef M. ; Beerenwinkel, Niko ; Horvath, Peter ; Dehio, Christoph ; Hardt, Wolf-Dietrich



Abstract

Salmonella Typhimurium (S. Tm) is a leading cause of diarrhea. The disease is triggered by pathogen invasion into the gut epithelium. Invasion is attributed to the SPI-1 type 3 secretion system (T1). T1 injects effector proteins into epithelial cells and thereby elicits rearrangements of the host cellular actin cytoskeleton and pathogen invasion. The T1 effector proteins SopE, SopB, SopE2 and ...

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