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Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

Siegmund, Daniela ; Kums, Juliane ; Ehrenschwender, Martin ; Wajant, Harald



Zusammenfassung

Macrophages express TNFR1 as well as TNFR2 and are also major producers of tumor necrosis factor (TNF), especially upon contact with pathogen-associated molecular patterns. Consequently, TNF not only acts as a macrophage-derived effector molecule but also regulates the activity and viability of macrophages. Here, we investigated the individual contribution of TNFR1 and TNFR2 to TNF-induced cell ...

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