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Sex-dependent alterations of Ca2+cycling in human cardiac hypertrophy and heart failure

Fischer, Thomas H. ; Herting, Jonas ; Eiringhaus, Jörg ; Pabel, Steffen ; Hartmann, Nico H. ; Ellenberger, David ; Friedrich, Martin ; Renner, André ; Gummert, Jan ; Maier, Lars S. ; Zabel, Markus ; Hasenfuss, Gerd ; Sossalla, Samuel



Abstract

Aims Clinical studies have shown differences in the propensity for malignant ventricular arrhythmias between women and men suffering from cardiomyopathies and heart failure (HF). This is clinically relevant as it impacts therapies like prophylactic implantable cardioverter-defibrillator implantation but the pathomechanisms are unknown. As an increased sarcoplasmic reticulum (SR) Ca2+ leak is ...

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