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Mesenchymal Stromal Cells Protect Endothelial Cells from Cytotoxic T Lymphocyte-Induced Lysis

Cahill, E. F. ; Sax, T. ; Hartmann, I. ; Haffner, S. ; Holler, E. ; Holler, B. ; Huss, R. ; Günther, C. ; Parolini, O. ; Kolch, W. ; Eissner, G.



Abstract

The integrity of the vasculature plays an important role in the success of allogeneic organ and haematopoietic stem cell transplantation. Endothelial cells (EC) have previously been shown to be the target of activated cytotoxic T lymphocytes (CTL) resulting in extensive cell lysis. Mesenchymal stromal cells (MSC) are multipotent cells which can be isolated from multiple sites, each demonstrating ...

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