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Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes

Suzuki, Toru ; Asami, Maki ; Hoffmann, Martin ; Lu, Xin ; Gužvić, Miodrag ; Klein, Christoph A. ; Perry, Anthony C. F.



Abstract

Sperm are highly differentiated and the activities that reprogram them for embryonic development during fertilization have historically been considered unique to the oocyte. We here challenge this view and demonstrate that mouse embryos in the mitotic cell cycle can also directly reprogram sperm for full-term development. Developmentally incompetent haploid embryos (parthenogenotes) injected with ...

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