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Fis Is Essential for Yersinia pseudotuberculosis Virulence and Protects against Reactive Oxygen Species Produced by Phagocytic Cells during Infection

Baumler, Andreas J ; Green, Erin R. ; Clark, Stacie ; Crimmins, Gregory T. ; Mack, Matthias ; Kumamoto, Carol A. ; Mecsas, Joan



Abstract

All three pathogenic Yersinia species share a conserved virulence plasmid that encodes a Type 3 Secretion System (T3SS) and its associated effector proteins. During mammalian infection, these effectors are injected into innate immune cells, where they block many bactericidal functions, including the production of reactive oxygen species (ROS). However, Y. pseudotuberculosis (Yptb) lacking the ...

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