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Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development

Schiechl, G. ; Hermann, F. J. ; Rodriguez Gomez, M. ; Kutzi, S. ; Schmidbauer, K. ; Talke, Y. ; Neumayer, S. ; Goebel, N. ; Renner, K. ; Brühl, H. ; Karasuyama, H. ; Obata-Ninomiya, K. ; Utpatel, K. ; Evert, M. ; Hirt, S. W. ; Geissler, E. K. ; Fichtner-Feigl, S. ; Mack, M.



Zusammenfassung

Fibrosis is a major component of chronic cardiac allograft rejection. Although several cell types are able to produce collagen, resident (donor-derived) fibroblasts are mainly responsible for excessive production of extracellular matrix proteins. It is currently unclear which cells regulate production of connective tissue elements in allograft fibrosis and how basophils, as potential producers of ...

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