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β-ketoenole dyes: Synthesis and study as fluorescent sensors for protein amyloid aggregates

Kovalska, Vladyslava ; Chernii, Svitlana ; Losytskyy, Mykhaylo ; Dovbii, Yan ; Tretyakova, Iryna ; Czerwieniec, Rafal ; Chernii, Victor ; Yarmoluk, Sergiy ; Volkov, Sergiy



Abstract

The series of the beta-ketoenoles (2E,5Z,7E,9E)-2-(alkylamino)-6-hydroxy-10-phenyldeca-2,5,7,9-tetraen-4-ones with variation of the alkylamino tail groups was synthesized and studied as potential probes for the sensing of protein insoluble aggregates - amyloid fibrils. Depending on the structure of the alkylamino group, the dyes could increase their fluorescence intensity in the dozens of times ...

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