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Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Chopra, Martin ; Biehl, Marlene ; Steinfatt, Tim ; Brandl, Andreas ; Kums, Juliane ; Amich, Jorge ; Vaeth, Martin ; Kuen, Janina ; Holtappels, Rafaela ; Podlech, Jürgen ; Mottok, Anja ; Kraus, Sabrina ; Jordán-Garrote, Ana-Laura ; Bäuerlein, Carina A. ; Brede, Christian ; Ribechini, Eliana ; Fick, Andrea ; Seher, Axel ; Polz, Johannes ; Ottmüller, Katja J. ; Baker, Jeanette ; Nishikii, Hidekazu ; Ritz, Miriam ; Mattenheimer, Katharina ; Schwinn, Stefanie ; Winter, Thorsten ; Schäfer, Viktoria ; Krappmann, Sven ; Einsele, Hermann ; Müller, Thomas D. ; Reddehase, Matthias J. ; Lutz, Manfred B. ; Männel, Daniela N. ; Berberich-Siebelt, Friederike ; Wajant, Harald ; Beilhack, Andreas



Abstract

Donor CD4(+) Foxp(3+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT [allo-HCT]). Current clinical study protocols rely on the ex vivo expansion of donor T reg cells and their infusion in high numbers. In this study, we present a novel strategy for inhibiting GvHD that is based on the in vivo expansion of ...

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