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G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ

Frasch, S. Courtney ; McNamee, Eóin N. ; Kominsky, Douglas ; Jedlicka, Paul ; Jakubzick, Claudia ; Zemski Berry, Karin ; Mack, Matthias ; Furuta, Glenn T. ; Lee, James J. ; Henson, Peter M. ; Colgan, Sean P. ; Bratton, Donna L.



Abstract

Proinflammatory consequences have been described for lysophosphatidylcholine, a lipid product of cellular injury, signaling via the G protein-coupled receptor G2A on myeloid and lymphoid inflammatory cells. This prompted the hypothesis that genetic deletion of G2A would limit intestinal inflammation in a mouse model of colitis induced by dextran sodium sulfate. Surprisingly, G2A(-/-) mice ...

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