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High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial

Illerhaus, Gerald ; Kasenda, Benjamin ; Ihorst, Gabriele ; Egerer, Gerlinde ; Lamprecht, Monika ; Keller, Ulrich ; Wolf, Hans-Heinrich ; Hirt, Carsten ; Stilgenbauer, Stephan ; Binder, Mascha ; Hau, Peter ; Edinger, Matthias ; Frickhofen, Norbert ; Bentz, Martin ; Möhle, Robert ; Röth, Alexander ; Pfreundschuh, Michael ; von Baumgarten, Louisa ; Deckert, Martina ; Hader, Claudia ; Fricker, Heidi ; Valk, Elke ; Schorb, Elisabeth ; Fritsch, Kristina ; Finke, Jürgen



Abstract

Background High-dose methotrexate-based chemotherapy is standard for primary CNS lymphoma, but most patients relapse. High-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT) is supposed to overcome the blood-brain barrier and eliminate residual disease in the CNS. We aimed to investigate the safety and efficacy of HCT-ASCT in patients with newly diagnosed primary CNS lymphoma. ...

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