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Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation

Schwartz, H. ; Blacher, E. ; Amer, M. ; Livneh, N. ; Abramovitz, L. ; Klein, A. ; Ben-Shushan, D. ; Soffer, S. ; Blazquez, R. ; Barrantes-Freer, A. ; Mu ller, M. ; Mu ller-Decker, K. ; Stein, R. ; Tsarfaty, G. ; Satchi-Fainaro, R. ; Umansky, V. ; Pukrop, T. ; Erez, N.



Abstract

Malignant melanoma is the deadliest of skin cancers. Melanoma frequently metastasizes to the brain, resulting in dismal survival. Nevertheless, mechanisms that govern early metastatic growth and the interactions of disseminated metastatic cells with the brain microenvironment are largely unknown. To study the hallmarks of brain metastatic niche formation, we established a transplantable model of ...

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