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Impact of adjuvants on CD4 + T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial

Leroux-Roels, Geert ; Marchant, Arnaud ; Levy, Jack ; Van Damme, Pierre ; Schwarz, Tino F. ; Horsmans, Yves ; Jilg, Wolfgang ; Kremsner, Peter G. ; Haelterman, Edwige ; Clément, Frédéric ; Gabor, Julian J. ; Esen, Meral ; Hens, Annick ; Carletti, Isabelle ; Fissette, Laurence ; Tavares Da Silva, Fernanda ; Burny, Wivine ; Janssens, Michel ; Moris, Philippe ; Didierlaurent, Arnaud M. ; Van Der Most, Robbert ; Garçon, Nathalie ; Van Belle, Pascale ; Van Mechelen, Marcelle


Immunogenicity and safety of different adjuvants combined with a model antigen (HBsAg) were compared. Healthy HBV-naive adults were randomized to receive HBs adjuvanted with alum or Adjuvant Systems AS01B, AS01E, AS03A or AS04 at Days 0 and 30. Different frequencies of HBs-specific CD4+ T cells 14 days post dose 2 but similar polyfunctionality profiles were induced by the different adjuvants with ...


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