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Comparative lipidomic analysis of synovial fluid in human and canine osteoarthritis

Kosinska, M. K. ; Mastbergen, S. C. ; Liebisch, G. ; Wilhelm, J. ; Dettmeyer, R. B. ; Ishaque, B. ; Rickert, M. ; Schmitz, G. ; Lafeber, F. P. ; Steinmeyer, J.


Objective: The lipid profile of synovial fluid (SF) is related to the health status of joints. The early stages of human osteoarthritis (OA) are poorly understood, which larger animals are expected to be able to model closely. This study examined whether the canine groove model of OA represents early OA in humans based on the changes in the lipid species profile in SF. Furthermore, the SF ...


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