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Epigenetic dynamics of monocyte-to-macrophage differentiation

Wallner, Stefan ; Schröder, Christopher ; Leitão, Elsa ; Berulava, Tea ; Haak, Claudia ; Beißer, Daniela ; Rahmann, Sven ; Richter, Andreas S. ; Manke, Thomas ; Bönisch, Ulrike ; Arrigoni, Laura ; Fröhler, Sebastian ; Klironomos, Filippos ; Chen, Wei ; Rajewsky, Nikolaus ; Müller, Fabian ; Ebert, Peter ; Lengauer, Thomas ; Barann, Matthias ; Rosenstiel, Philip ; Gasparoni, Gilles ; Nordström, Karl ; Walter, Jörn ; Brors, Benedikt ; Zipprich, Gideon ; Felder, Bärbel ; Klein-Hitpass, Ludger ; Attenberger, Corinna ; Schmitz, Gerd ; Horsthemke, Bernhard



Abstract

Background: Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to analyze the complete transcriptome and epigenome of human monocytes that were differentiated in vitro by addition of colony-stimulating factor 1 in serum-free medium. Results: ...

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