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Hypertensive retinopathy in a transgenic angiotensin-based model

Reichhart, Nadine ; Haase, Nadine ; Crespo-Garcia, Sergio ; Skosyrski, Sergej ; Herrspiegel, Christina ; Kociok, Norbert ; Fuchshofer, Rudolf ; Dillinger, Andrea ; Poglitsch, Marco ; Müller, Dominik N. ; Joussen, Antonia M. ; Luft, Friedrich C. ; Dechend, Ralf ; Strauß, Olaf



Abstract

Severe hypertension destroys eyesight. The RAS (renin-angiotensin system) may contribute to this. This study relied on an established angiotensin, AngII (angiotensin II)-elevated dTGR (double-transgenic rat) model and same-background SD (Sprague-Dawley) rat controls. In dTGRs, plasma levels of AngII were increased. We determined the general retinal phenotype and observed degeneration of ganglion ...

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