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Periodontal ligament cells as alternative source for cell-based therapy of tendon injuries: in vivo study of full-size Achilles tendon defect in a rat model

Hsieh, C.-F. ; Alberton, P. ; Loffredo-Verde, E. ; Volkmer, E. ; Pietschmann, M. ; Müller, P. E. ; Schieker, M. ; Docheva, D.



Abstract

Tendon's natural healing potential is extremely low and inefficient, with significant dysfunction and disability due to hypocellularity and hypovascularity of tendon tissues. The application of stem cells can aid in significantly enhanced repair of tendon rupture; therefore, the main aim of this study is to assess the potential of using periodontal ligament cells (PDL), usually obtained from ...

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