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Exercise training reverses myocardial dysfunction induced by CaMKIIδCoverexpression by restoring Ca2+homeostasis

Høydal, Morten A. ; Stølen, Tomas O. ; Kettlewell, Sarah ; Maier, Lars S. ; Brown, Joan Heller ; Sowa, Tomas ; Catalucci, Daniele ; Condorelli, Gianluigi ; Kemi, Ole J. ; Smith, Godfrey L. ; Wisløff, Ulrik



Abstract

Several conditions of heart disease, including heart failure and diabetic cardiomyopathy, are associated with upregulation of cytosolic Ca2+ /calmodulin-dependent protein kinase II (CaMKII delta(C)) activity. In the heart, CaMKII delta(C) isoform targets several proteins involved in intracellular Ca2+ homeostasis. We hypothesized that high-intensity endurance training activates mechanisms that ...

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