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Expression and gene doses changes of the p53-regulator PPM1D in meningiomas: a role in meningioma progression?

Fukami, Shinjiro ; Riemenschneider, Markus J. ; Kohno, Michihiro ; Steiger, Hans Jakob



Abstract

The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningiomas (WHO grade I, 20 cases; grade II, 17 cases; grade III, 20 cases). For ...

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