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Peripheral Motor and Sensory Nerve Conduction following Transplantation of Undifferentiated Autologous Adipose Tissue–Derived Stem Cells in a Biodegradable U.S. Food and Drug Administration–Approved Nerve Conduit

Klein, Silvan M. ; Vykoukal, Jody ; Li, De-Pei ; Pan, Hui-Lin ; Zeitler, Katharina ; Alt, Eckhard ; Geis, Sebastian ; Felthaus, Oliver ; Prantl, Lukas


Background: Conduits preseeded with either Schwann cells or stem cells differentiated into Schwann cells demonstrated promising results for the outcome of nerve regeneration in nerve defects. Methods: The concept of this trial combines nerve repair by means of a commercially available nerve guidance conduit and preseeding with autologous, undifferentiated, adipose tissue-derived stem cells. ...


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