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The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis

Hartz, Bernd ; Marsh, Rebecca ; Rao, Kanchan ; Henter, Jan-Inge ; Jordan, Michael ; Filipovich, Lisa ; Bader, Peter ; Beier, Rita ; Burkhardt, Birgit ; Meisel, Roland ; Schulz, Ansgar ; Winkler, Beate ; Albert, Michael H. ; Greil, Johann ; Karasu, Gülsün ; Woessmann, Wilhelm ; Corbacioglu, Selim ; Gruhn, Bernd ; Holter, Wolfgang ; Kühl, Jörn-Sven ; Lang, Peter ; Seidel, Markus G. ; Veys, Paul ; Löfstedt, Alexandra ; Ammann, Sandra ; Ehl, Stephan ; Janka, Gritta ; Müller, Ingo ; Lehmberg, Kai



Abstract

Reduced-intensity conditioning has improved survival after hematopoietic stem cell transplantation (HSCT) for hemophagocytic lymphohistiocytosis (HLH) at the cost of more frequent mixed chimerism. The minimum level of donor chimerism (DC) required to prevent HLH reactivation in humans remains to be determined. In a multicenter retrospective study, 103 patients transplanted for hereditary HLH ...

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